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Article

Protein Engineering on Human Recombinant Follistatin: Enhancing Pharmacokinetic Characteristics for Therapeutic Application.

The Journal of pharmacology and experimental therapeutics - 1 Aug 2018

Shen Chuan, Iskenderian Andrea, Lundberg Dianna, He Tao, Palmieri Kathleen, Crooker Robert, Deng Qingwei, Traylor Matthew, Gu Sheng, Rong Haojing, Ehmann David, Pescatore Brian, Strack-Logue Bettina, Romashko Alla, Baviello George, Gill John, Zhang Bohong, Meiyappan Muthuraman, Pan Clark, Norton Angela W

Abstract excerpt

Follistatin (FS) is an important regulatory protein, a natural antagonist for transforming growth factor-β family members activin and myostatin. The diverse biologic roles of the activin and myostatin signaling pathways make FS a promising therapeutic target for treating human diseases exhibiting inflammation, fibrosis, and muscle disorders, such as Duchenne muscular dystrophy. However, rapid heparin-mediated...

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Identifiers

PMID: 29752426
DOI: 10.1124/jpet.118.248195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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