Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased thermal stability of FGF10 leads to ectopic signaling during development

21 Apr 2025

Abstract excerpt

Fibroblast growth factors (FGFs) control organ morphogenesis during development as well as tissue homeostasis and repair in the adult organism. Despite their importance, many mechanisms that regulate FGF function are still poorly understood. Interestingly, the thermodynamic stability of 22 mammalian FGFs varies widely, with some FGFs remaining stable at body temperature for more than 24 h, while others lose their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Fibroblast Growth Factor Research
Share to Neonatal Respiratory Health Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40257501
DOI: 10.1007/s00018-025-05681-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased thermal stability of FGF10 leads to ectopic signaling during developmentPMID 40257501Read ↗

Instability restricts signaling of multiple fibroblast growth factors.Semantic proximity Read ↗

Highly stable mutants of human fibroblast growth factor-1 exhibit prolonged biological action.Semantic proximity Read ↗

Molecular mechanisms of fibroblast growth factor signaling in physiology and pathology.Semantic proximity Read ↗

Application of bioinformatics and molecular dynamics simulation approaches for identification of fibroblast growth factor 10 analogues with potentially improved thermostability.Semantic proximity Read ↗

Thermal stability of fibroblast growth factor protein is a determinant factor in regulating self-renewal, differentiation, and reprogramming in human pluripotent stem cells.Semantic proximity Read ↗

Fibroblast growth factor 10.Semantic proximity Read ↗

Structural and biochemical investigation into stable FGF2 mutants with novel mutation sites and hydrophobic replacements for surface-exposed cysteines.Semantic proximity Read ↗

Thermodynamic characterization of mutants of human fibroblast growth factor 1 with an increased physiological half-life.Semantic proximity Read ↗

HtrA1 is a novel antagonist controlling fibroblast growth factor (FGF) signaling via cleavage of FGF8.Semantic proximity Read ↗

Structure and expression of a novel isoform of mouse FGF homologous factor (FHF)-4.Semantic proximity Read ↗

Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix.Semantic proximity Read ↗

Regulation of Receptor Binding Specificity of FGF9 by an Autoinhibitory Homodimerization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.