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Article

Complex relationship between ligand binding and dimerization in the epidermal growth factor receptor.

Cell reports - 20 Nov 2014

Bessman Nicholas J, Bagchi Atrish, Ferguson Kathryn M, Lemmon Mark A

Abstract excerpt

The epidermal growth factor receptor (EGFR) plays pivotal roles in development and is mutated or overexpressed in several cancers. Despite recent advances, the complex allosteric regulation of EGFR remains incompletely understood. Through efforts to understand why the negative cooperativity observed for intact EGFR is lost in studies of its isolated extracellular region (ECR), we uncovered unexpected...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 25453753
DOI: 10.1016/j.celrep.2014.10.010
PMCID: PMC4254573

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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