Article
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations.
Science (New York, N.Y.) - 7 Feb 2020
Wilmes Stephan, Hafer Maximillian, Vuorio Joni, Tucker Julie A, Winkelmann Hauke, Löchte Sara, Stanly Tess A, Pulgar Prieto Katiuska D, Poojari Chetan, Sharma Vivek, Richter Christian P, Kurre Rainer, Hubbard Stevan R, Garcia K Christopher, Moraga Ignacio, Vattulainen Ilpo, Hitchcock Ian S, Piehler Jacob
Abstract excerpt
Homodimeric class I cytokine receptors are assumed to exist as preformed dimers that are activated by ligand-induced conformational changes. We quantified the dimerization of three prototypic class I cytokine receptors in the plasma membrane of living cells by single-molecule fluorescence microscopy. Spatial and spatiotemporal correlation of individual receptor subunits showed ligand-induced dimerization and...
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