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Article

Autoinhibitory mechanism for the mutation-induced impaired FGF9 signaling.

Journal of chemical information and modeling - 24 Sept 2012

Wang Ying, Wu Xiao-Lin, Wei Dong-Qing, Li Yi-Xue, Wang Jing-Fang

Abstract excerpt

Fibroblast growth factor 9 (FGF9), an important member of the fibroblast growth factor (FGF) family, can bind with high affinity to FGFR3 in a heparin-dependent approach. In humans, the deletions and mutations resulting in dysfunction of the FGF9 signaling can cause human skeletal dysplasia and cancers. A mutation (S99N) in this protein has been identified to be associated with significantly impaired FGF...

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Source

Identifiers

PMID: 22920789
DOI: 10.1021/ci3003045

Genes

FGF9
FGFR3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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