Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The ordered transmission disequilibrium test: detection of modifier genes.

Genetic epidemiology - 1 Jan 2009

Perdry Hervé, Babron Marie-Claude, Clerget-Darpoux Françoise

Abstract excerpt

We consider the problem of detection of modifier genes that lead to variations in a disease-related continuous variable (DRCV), such as the age of onset or a measure of disease severity, in a strategy of candidate genes. We propose a novel method, the ordered transmission disequilibrium test (OTDT), to test for a relation between the clinical heterogeneity expressed by a DRCV and marker genotypes of a candidate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Epidemiologic Methods
Share to Genetic Diseases, Inborn

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Techniques

Share to Linear Models

Share to Linkage Disequilibrium

Share to Models, Genetic

Share to Models, Statistical

Source

Identifiers

PMID: 19548341
DOI: 10.1002/gepi.20348

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The ordered transmission disequilibrium test: detection of modifier genes.PMID 19548341Read ↗

A novel test for detecting gene-gene interactions in trio studiesSemantic proximity Read ↗

Identifying Causal Genotype-Phenotype Relationships for Population-Sampled Parent-Child Trios.Semantic proximity Read ↗

A general test of association for complex diseases with variable age of onset.Semantic proximity Read ↗

Using unaffected child trios to test for transmission distortion.Semantic proximity Read ↗

Genetic association tests with age at onset.Semantic proximity Read ↗

Comparison of linkage-disequilibrium methods for localization of genes influencing quantitative traits in humans.Semantic proximity Read ↗

Multipoint linkage disequilibrium mapping for complex diseases.Semantic proximity Read ↗

Analysis of complex human genetic traits: an ordered-notation method and new tests for mode of inheritance.Semantic proximity Read ↗

The family based association test method: strategies for studying general genotype--phenotype associations.Semantic proximity Read ↗

The power of the transmission disequilibrium test (TDT) with both case-parent and control-parent trios.Semantic proximity Read ↗

An extended transmission/disequilibrium test (TDT) for multi-allele marker loci.Semantic proximity Read ↗

Effects of age at onset on the power of the affected sib pair and transmission/disequilibrium tests.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.