Using unaffected child trios to test for transmission distortion.

doi:10.1002/1098-2272(200012)19:4<381::AID-GEPI9>3.0.CO;2-B

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Article

Using unaffected child trios to test for transmission distortion.

Genetic epidemiology - 1 Dec 2000

Scott L, Rogus J J

Abstract excerpt

The transmission disequilibrium test (TDT), an alternative to case-control analysis that is not influenced by population stratification, focuses on affected child trios (ACTs) comprising affected cases and their parents. Unaffected child trios (UCTs) have also been proposed but mainly to rule out segregation distortion. To explore situations when UCTs are preferable to detect transmission distortion, we compared...

Topics

Child
Family Health
Genetic Predisposition to Disease
Humans
Linkage Disequilibrium
Models, Genetic
Models, Statistical
Molecular Epidemiology
Prevalence
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 11108647
DOI: 10.1002/1098-2272(200012)19:4<381::AID-GEPI9>3.0.CO;2-B

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