Article
The family based association test method: strategies for studying general genotype--phenotype associations.
European journal of human genetics : EJHG - 1 Apr 2001
Horvath S, Xu X, Laird N M
Abstract excerpt
With possibly incomplete nuclear families, the family based association test (FBAT) method allows one to evaluate any test statistic that can be expressed as the sum of products (covariance) between an arbitrary function of an offspring's genotype with an arbitrary function of the offspring's phenotype. We derive expressions needed to calculate the mean and variance of these test statistics under the null...
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