Identifying Causal Genotype-Phenotype Relationships for Population-Sampled Parent-Child Trios.

Abstract excerpt

The process by which genes are transmitted from parent to child provides a source of randomization preceding all other factors that may causally influence any particular child phenotype. Because of this, it is natural to consider genetic transmission as a source of experimental randomization. In this work, we show how parent-child trio data can be leveraged to identify causal genetic loci by modeling the...

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