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Article

Mosaic genetic screen for suppressors of the de2f1 mutant phenotype in Drosophila.

Genetics - 1 Sept 2009

Ambrus Aaron M, Rasheva Vanya I, Nicolay Brandon N, Frolov Maxim V

Abstract excerpt

The growth suppressive function of the retinoblastoma (pRB) tumor suppressor family is largely attributed to its ability to negatively regulate the family of E2F transcriptional factors and, as a result, to repress E2F-dependent transcription. Deregulation of the pRB pathway is thought to be an obligatory event in most types of cancers. The large number of mammalian E2F proteins is one of the major obstacles that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19546319
DOI: 10.1534/genetics.109.104661
PMCID: PMC2746169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mosaic genetic screen for suppressors of the de2f1 mutant phenotype in Drosophila.PMID 19546319Read ↗

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A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression.Semantic proximity Read ↗

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