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Article

Functional antagonism between E2F family members.

Genes & development - 15 Aug 2001

Frolov M V, Huen D S, Stevaux O, Dimova D, Balczarek-Strang K, Elsdon M, Dyson N J

Abstract excerpt

E2F is a heterogenous transcription factor and its role in cell cycle control results from the integrated activities of many different E2F family members. Unlike mammalian cells, that have a large number of E2F-related genes, the Drosophila genome encodes just two E2F genes, de2f1 and de2f2. Here we show that de2f1 and de2f2 provide different elements of E2F regulation and that they have opposing functions during...

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Identifiers

PMID: 11511545
DOI: 10.1101/gad.903901
PMCID: PMC312757

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Source receipt: pubmed, retrieved 7 Sept 2026.

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