Article
Rbf1 degron dysfunction enhances cellular DNA replication.
Cell cycle (Georgetown, Tex.) - 15 Oct 2012
Raj Nitin, Zhang Liang, Wei Yiliang, Arnosti David N, Henry R William
Abstract excerpt
The E2F family of transcription factors contributes to oncogenesis through activation of multiple genes involved in cellular proliferation, a process that is opposed by the Retinoblastoma tumor suppressor protein (RB). RB also increases E2F1 stability by inhibiting its proteasome-mediated degradation, but the consequences of this post-translational regulation of E2F1 remain unknown. To better understand the...
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