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Article

G1 cyclin-dependent kinases are insufficient to reverse dE2F2-mediated repression.

Genes & development - 15 Mar 2003

Frolov Maxim V, Stevaux Olivier, Moon Nam-Sung, Dimova Dessislava, Kwon Eun-Jeong, Morris Erick J, Dyson Nicholas J

Abstract excerpt

Here we show that the cell cycle defects of dE2F1-depleted cells depend on the cooperative effects of dE2F2 and DACAPO (DAP), an inhibitor of Cyclin E/cyclin-dependent kinase 2 (CycE/cdk2). The different properties of cells lacking dE2F1/dE2F2 and dE2F1/DAP lead to the surprising observation that dE2F2-mediated repression differs from retinoblastoma family protein 1 (RBF1) inhibition of dE2F1, and is resistant to...

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Identifiers

PMID: 12651890
DOI: 10.1101/gad.1031803
PMCID: PMC196013

Genes

DAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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G1 cyclin-dependent kinases are insufficient to reverse dE2F2-mediated repression.PMID 12651890Read ↗

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