Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Retinoblastoma family 2 is required in vivo for the tissue-specific repression of dE2F2 target genes.

Cell cycle (Georgetown, Tex.) - 1 Sept 2005

Stevaux Olivier, Dimova Dessislava K, Ji Jun-Yuan, Moon Nam Sung, Frolov Maxim V, Dyson Nicholas J

Abstract excerpt

In higher eukaryotes, the Retinoblastoma and E2F families of proteins control the transcription of a large number of target genes. Here, we have mutated the second Drosophila Retinoblastoma family gene (Rbf2), and contrasted the in vivo molecular functions of RBF2 with dE2F2, the only E2F partner of RBF2. Previous studies failed to uncover a unique role for RBF2 in E2F regulation. Here we find that RBF2 functions...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Northern
Share to Chromatin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromatin Immunoprecipitation

Share to Embryo, Nonmammalian

Share to Genome

Share to Microscopy, Electron, Scanning

Share to Transgenes

Source

Identifiers

PMID: 16082225
DOI: 10.4161/cc.4.9.1982

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Retinoblastoma family 2 is required in vivo for the tissue-specific repression of dE2F2 target genes.PMID 16082225Read ↗

RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes.Semantic proximity Read ↗

RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila.Semantic proximity Read ↗

Suppression of the rbf null mutants by a de2f1 allele that lacks transactivation domain.Semantic proximity Read ↗

Rbf1 degron dysfunction enhances cellular DNA replication.Semantic proximity Read ↗

Mosaic genetic screen for suppressors of the de2f1 mutant phenotype in Drosophila.Semantic proximity Read ↗

RBF and Rno promote photoreceptor differentiation onset through modulating EGFR signaling in the Drosophila developing eye.Semantic proximity Read ↗

Functional antagonism between E2F family members.Semantic proximity Read ↗

RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes.Semantic proximity Read ↗

Novel functions for the transcription factor E2F4 in development and diseaseSemantic proximity Read ↗

dREAM co-operates with insulator-binding proteins and regulates expression at divergently paired genes.Semantic proximity Read ↗

Paradoxical instability-activity relationship defines a novel regulatory pathway for retinoblastoma proteins.Semantic proximity Read ↗

DNA-binding and trans-activation properties of Drosophila E2F and DP proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.