Suppression of the rbf null mutants by a de2f1 allele that lacks transactivation domain.

Abstract excerpt

In mammals, a large number of proteins including E2F transcription factors have been shown to interact with the tumor suppressor gene product pRB, but it is not clear to what extend the function of pRB is mediated by E2F. In addition, E2F was shown to mediate both transcription activation and repression; it remains to be tested which function of E2F is critical for normal development. Drosophila homologs of the...

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