Article
Mutant mouse models reveal the relative roles of E2F1 and E2F3 in vivo.
Molecular and cellular biology - 1 Apr 2002
Cloud Jennifer E, Rogers Catherine, Reza Tammi L, Ziebold Ulrike, Stone James R, Picard Michael H, Caron Alicia M, Bronson Roderick T, Lees Jacqueline A
Abstract excerpt
The E2F1, -2, and -3 transcription factors are key downstream targets of the retinoblastoma protein (pRB) tumor suppressor that drive expression of proliferation-associated genes. Here we use mutant mouse strains to investigate E2F3's role in vivo. We show that E2F3 is essential for embryonic viability in the pure 129/Sv background but the presence of C57BL/6 alleles yields some adult survivors. Although growth...
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