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Article

RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila.

Genes & development - 15 May 1996

Du W, Vidal M, Xie J E, Dyson N

Abstract excerpt

Genetic studies have shown that cyclin E and dE2F are critical regulators of S-phase entry during Drosophila embryogenesis. Whereas the ectopic expression of cyclin E activates dE2F-dependent transcription, it has been proposed that cyclin E does not act directly on dE2F but targets a negative re...

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Identifiers

PMID: 8675008
DOI: 10.1101/gad.10.10.1206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8675008-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila.PMID 8675008Read ↗

RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes.Semantic proximity Read ↗

Suppression of the rbf null mutants by a de2f1 allele that lacks transactivation domain.Semantic proximity Read ↗

Retinoblastoma family 2 is required in vivo for the tissue-specific repression of dE2F2 target genes.Semantic proximity Read ↗

Functional antagonism between E2F family members.Semantic proximity Read ↗

Rbf1 degron dysfunction enhances cellular DNA replication.Semantic proximity Read ↗

The role of RBF in developmentally regulated cell proliferation in the eye disc and in Cyclin D/Cdk4 induced cellular growth.Semantic proximity Read ↗

dDP is needed for normal cell proliferation.Semantic proximity Read ↗

The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis.Semantic proximity Read ↗

DNA-binding and trans-activation properties of Drosophila E2F and DP proteins.Semantic proximity Read ↗

Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.Semantic proximity Read ↗

Mosaic genetic screen for suppressors of the de2f1 mutant phenotype in Drosophila.Semantic proximity Read ↗

A Balance of Yki/Sd Activator and E2F1/Sd Repressor Complexes Controls Cell Survival and Affects Organ SizeSemantic proximity Read ↗

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