Article
dE2F2-independent rescue of proliferation in cells lacking an activator dE2F1.
Molecular and cellular biology - 1 Dec 2007
Ambrus Aaron M, Nicolay Brandon N, Rasheva Vanya I, Suckling Richard J, Frolov Maxim V
Abstract excerpt
In Drosophila melanogaster, the loss of activator de2f1 leads to a severe reduction in cell proliferation and repression of E2F targets. To date, the only known way to rescue the proliferation block in de2f1 mutants was through the inactivation of dE2F2. This suggests that dE2F2 provides a major contribution to the de2f1 mutant phenotype. Here, we report that in mosaic animals, in addition to de2f2, the loss of a...
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