Article
A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression.
Proceedings of the National Academy of Sciences of the United States of America - 29 May 2007
Lu Jianrong, Ruhf Marie-Laure, Perrimon Norbert, Leder Philip
Abstract excerpt
Regulation of chromatin structure is critical in many fundamental cellular processes. Previous studies have suggested that the Rb tumor suppressor may recruit multiple chromatin regulatory proteins to repress E2F, a key regulator of cell proliferation and differentiation. Taking advantage of the evolutionary conservation of the E2F pathway, we have conducted a genome-wide RNAi screen in cultured Drosophila cells...
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