Article
The Balpha and Bdelta regulatory subunits of PP2A are necessary for assembly of the CaMKIV.PP2A signaling complex.
Biochemical and biophysical research communications - 4 Sept 2009
Reece Kelie M, Mazalouskas Matthew D, Wadzinski Brian E
Abstract excerpt
Calcium/calmodulin-dependent protein kinase IV (CaMKIV) is a serine/threonine kinase that is important in synaptic plasticity and T cell maturation. Activation of CaMKIV requires calcium/calmodulin binding and phosphorylation at T200 by CaMK kinase. Our previous work has shown that protein serine/threonine phosphatase 2A (PP2A) forms a complex with CaMKIV and negatively regulates its activity. Here we demonstrate...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
