Article
A Novel Interaction of the Catalytic Subunit of Protein Phosphatase 2A with the Adaptor Protein CIN85 Suppresses Phosphatase Activity and Facilitates Platelet Outside-in αIIbβ3 Integrin Signaling.
The Journal of biological chemistry - 12 Aug 2016
Khatlani Tanvir, Pradhan Subhashree, Da Qi, Shaw Tanner, Buchman Vladimir L, Cruz Miguel A, Vijayan K Vinod
Abstract excerpt
The transduction of signals generated by protein kinases and phosphatases are critical for the ability of integrin αIIbβ3 to support stable platelet adhesion and thrombus formation. Unlike kinases, it remains unclear how serine/threonine phosphatases engage the signaling networks that are initiated following integrin ligation. Because protein-protein interactions form the backbone of signal transduction, we...
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