Article
The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines.
Nature communications - 31 Oct 2016
Liang Zhuoyi, Zhan Yi, Shen Yang, Wong Catherine C L, Yates John R, Plattner Florian, Lai Kwok-On, Ip Nancy Y
Abstract excerpt
Dendritic spine stabilization depends on afferent synaptic input and requires changes in actin cytoskeleton dynamics and protein synthesis. However, the underlying molecular mechanism remains unclear. Here we report the identification of 'calmodulin kinase-like vesicle-associated' (CaMKv), a pseudokinase of the CaMK family with unknown function, as a synaptic protein crucial for dendritic spine maintenance. CaMKv...
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