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Article

CaMKII is essential for the cellular clock and coupling between morning and evening behavioral rhythms.

Genes & development - 15 May 2014

Kon Naohiro, Yoshikawa Tomoko, Honma Sato, Yamagata Yoko, Yoshitane Hikari, Shimizu Kimiko, Sugiyama Yasunori, Hara Chihiro, Kameshita Isamu, Honma Ken-ichi, Fukada Yoshitaka

Abstract excerpt

Daily behavioral rhythms in mammals are governed by the central circadian clock, located in the suprachiasmatic nucleus (SCN). The behavioral rhythms persist even in constant darkness, with a stable activity time due to coupling between two oscillators that determine the morning and evening activities. Accumulating evidence supports a prerequisite role for Ca(2+) in the robust oscillation of the SCN, yet the...

Topics

ARNTL Transcription Factors
Animals
Behavior, Animal
Biological Clocks
CLOCK Proteins
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Circadian Rhythm
Enzyme Activation
Enzyme Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation

Male

Mice

Mice, Inbred C57BL

Mutation

NIH 3T3 Cells

Neurons

Phosphorylation

Rats

Source

Open in PubMed Open full text

Identifiers

PMID: 24831701
DOI: 10.1101/gad.237511.114
PMCID: PMC4035538

Genes

BMAL1
CLOCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-24831701-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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