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Article

Channel-anchored protein kinase CK2 and protein phosphatase 1 reciprocally regulate KCNQ2-containing M-channels via phosphorylation of calmodulin.

The Journal of biological chemistry - 18 Apr 2014

Kang Seungwoo, Xu Mingxuan, Cooper Edward C, Hoshi Naoto

Abstract excerpt

M-type potassium channels, encoded by the KCNQ family genes (KCNQ2-5), require calmodulin as an essential co-factor. Calmodulin bound to the KCNQ2 subunit regulates channel trafficking and stabilizes channel activity. We demonstrate that phosphorylation of calmodulin by protein kinase CK2 (casein kinase 2) rapidly and reversibly modulated KCNQ2 current. CK2-mediated phosphorylation of calmodulin strengthened its...

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Identifiers

PMID: 24627475
DOI: 10.1074/jbc.M113.528497
PMCID: PMC4036288

Genes

KCNQ2

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Channel-anchored protein kinase CK2 and protein phosphatase 1 reciprocally regulate KCNQ2-containing M-channels via phosphorylation of calmodulin.PMID 24627475Read ↗

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