Article
Role of phosphorylation and basic residues in the catalytic domain of cytosolic phospholipase A2alpha in regulating interfacial kinetics and binding and cellular function.
The Journal of biological chemistry - 3 Apr 2009
Tucker Dawn E, Ghosh Moumita, Ghomashchi Farideh, Loper Robyn, Suram Saritha, John Bonnie St, Girotti Milena, Bollinger James G, Gelb Michael H, Leslie Christina C
Abstract excerpt
Group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) is regulated by phosphorylation and calcium-induced translocation to membranes. Immortalized mouse lung fibroblasts lacking endogenous cPLA(2)alpha (IMLF(-/-)) were reconstituted with wild type and cPLA(2)alpha mutants to investigate how calcium, phosphorylation, and the putative phosphatidylinositol 4,5-bisphosphate (PIP(2)) binding site regulate...
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