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Article

A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A.

Science (New York, N.Y.) - 22 May 1998

Westphal R S, Anderson K A, Means A R, Wadzinski B E

Abstract excerpt

Stimulation of T lymphocytes results in a rapid increase in intracellular calcium concentration ([Ca2+]i) that parallels the activation of Ca2+-calmodulin-dependent protein kinase IV (CaMKIV), a nuclear enzyme that can phosphorylate and activate the cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB). However, inactivation of CaMKIV occurs despite the sustained increase in [Ca2+]i that...

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Identifiers

PMID: 9596578
DOI: 10.1126/science.280.5367.1258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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