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Article

Structure-Function analysis of the CTLA-4 interaction with PP2A.

BMC immunology - 30 Apr 2009

Teft Wendy A, Chau Thu A, Madrenas Joaquín

Abstract excerpt

BACKGROUND: CTLA-4 functions primarily as an inhibitor of T cell activation. There are several candidate explanations as to how CTLA-4 modulates T cell responses, but the exact mechanism remains undefined. The tail of CTLA-4 does not have any intrinsic enzymatic activity but is able to associate with several signaling molecules including the serine/threonine phosphatase PP2A. PP2A is a heterotrimeric molecule...

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Identifiers

PMID: 19405949
DOI: 10.1186/1471-2172-10-23
PMCID: PMC2683795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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