Article
Accelerated decline in lung function in cigarette smokers is associated with TP53/MDM2 polymorphisms.
Human genetics - 1 Oct 2009
Hancox Robert J, Poulton Richie, Welch David, Olova Nelly, McLachlan Christene R, Greene Justina M, Sears Malcolm R, Caspi Avshalom, Moffitt Terrie E, Robertson Stephen P, Braithwaite Antony W
Abstract excerpt
In vitro studies have shown that p53 mediates a protective response against DNA damage by causing either cell-cycle arrest and DNA repair, or apoptosis. These responses have not yet been demonstrated in humans. A common source of DNA damage in humans is cigarette smoke, which should activate p53 repair mechanisms. As the level of p53 is regulated by MDM2, which targets p53 for degradation, the G-allele of a...
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