Article
Elevated risk of squamous-cell carcinoma of the lung in heavy smokers carrying the variant alleles of the TP53 Arg72Pro and p21 Ser31Arg polymorphisms.
Lung cancer (Amsterdam, Netherlands) - 1 Jan 2007
Popanda Odilia, Edler Lutz, Waas Peter, Schattenberg Torsten, Butkiewicz Dorota, Muley Thomas, Dienemann Hendrik, Risch Angela, Bartsch Helmut, Schmezer Peter
Abstract excerpt
Alterations in cell cycle regulation and apoptosis leading to malignant transformation could be caused by common genetic variants in tumor suppressor genes. The effects of the TP53 polymorphism Arg72Pro on lung cancer risk have been investigated in numerous studies with, however, conflicting results. In many studies, important risk modifiers such as smoking or tumor histology were not taken into account. We...
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