Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene.

doi:10.1186/1471-2407-8-113

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Article

Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene.

BMC cancer - 23 Apr 2008

Mittelstrass Kirstin, Sauter Wiebke, Rosenberger Albert, Illig Thomas, Timofeeva Maria, Klopp Norman, Dienemann Hendrik, Meese Eckart, Sybrecht Gerhard, Woelke Gabi, Cebulla Mathias, Degen Maria, Morr Harald, Drings Peter, Groeschel Andreas, Kreymborg Karsten Grosse, Haeussinger Karl, Hoeffken Gerd, Schmidt Christine, Jilge Bettina, Schmidt Wilhelm, Ko You-Dschun, Taeuscher Dagmar, Chang-Claude Jenny, Wichmann Heinz-Erich, Bickeboeller Heike, Risch Angela

Abstract excerpt

The polymorphism SNP309 (rs2279744) in the promoter region of the MDM2 gene has been shown to alter protein expression and may play a role in the susceptibility to lung cancer. The MDM2 protein is a key inhibitor of p53 and several mechanisms of MDM2/p53 interactions are presently known: modulati...

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PMID: 18433484
DOI: 10.1186/1471-2407-8-113
PMCID: PMC2377274

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MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18433484-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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