Article
Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancer.
Human mutation - 1 Jan 2006
Zhang Xuemei, Miao Xiaoping, Guo Yongli, Tan Wen, Zhou Yifeng, Sun Tong, Wang Yonggang, Lin Dongxin
Abstract excerpt
The tumor suppressor TP53 pathway plays a crucial role in preventing carcinogenesis through its ability to impose cell cycle arrest and apoptosis following DNA damage and oncogene activation. MDM2 is a key negative regulator of the TP53 pathway and is overexpressed in many cancers as oncoprotein. We investigated the association between genetic variation in the promoter region of MDM2 (c.-5+309G>T,...
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