Genetic polymorphisms of MDM2, cumulative cigarette smoking and nonsmall cell lung cancer risk.

doi:10.1002/ijc.23178

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Article

Genetic polymorphisms of MDM2, cumulative cigarette smoking and nonsmall cell lung cancer risk.

International journal of cancer - 15 Feb 2008

Liu Geoffrey, Wheatley-Price Paul, Zhou Wei, Park Sohee, Heist Rebecca S, Asomaning Kofi, Wain John C, Lynch Thomas J, Su Li, Christiani David C

Abstract excerpt

Abnormalities of the tumor suppressor TP53 pathway are critical in the development of many cancers since it regulates cell cycle components and apoptosis. Murine double minute-2 (MDM2) protein is a central node in the p53 pathway and a direct negative regulator of p53. The MDM2 SNP309 (rs2279744) polymorphism increases MDM2 RNA and protein levels, attenuating the p53 pathway. The MDM2 SNP309 polymorphism was...

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PMID: 17957785
DOI: 10.1002/ijc.23178

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MDM2

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