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Article

MDM2 gene promoter polymorphisms and risk of lung cancer: a case-control analysis.

Carcinogenesis - 1 Oct 2006

Li Guojun, Zhai Xiaodong, Zhang Zhengdong, Chamberlain Robert M, Spitz Margaret R, Wei Qingyi

Abstract excerpt

The MDM2 protein negatively regulates p53 expression level in modulating DNA repair, cell-cycle control, cell growth and apoptosis. Polymorphisms in the promoter region of the MDM2 gene have been shown to alter protein expression and may, thus, play a role in carcinogenesis. To test our hypothesi...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16675470
DOI: 10.1093/carcin/bgl047

Genes

MDM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16675470-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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