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Article

p53 polymorphisms: cancer implications.

Nature reviews. Cancer - 1 Feb 2009

Whibley Catherine, Pharoah Paul D P, Hollstein Monica

Abstract excerpt

The normal functioning of p53 is a potent barrier to cancer. Tumour-associated mutations in TP53, typically single nucleotide substitutions in the coding sequence, are a hallmark of most human cancers and cause dramatic defects in p53 function. By contrast, only a small fraction, if any, of the >200 naturally occurring sequence variations (single nucleotide polymorphisms, SNPs) of TP53 in human populations are...

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Source

Identifiers

PMID: 19165225
DOI: 10.1038/nrc2584

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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