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Article

p53 Signaling Pathway Polymorphisms Associated With Emphysematous Changes in Patients With COPD.

Chest - 1 Jul 2017

Mizuno Shiro, Ishizaki Takeshi, Kadowaki Maiko, Akai Masaya, Shiozaki Kohei, Iguchi Masaharu, Oikawa Taku, Nakagawa Ken, Osanai Kazuhiro, Toga Hirohisa, Gomez-Arroyo Jose, Kraskauskas Donatas, Cool Carlyne D, Bogaard Herman J, Voelkel Norbert F

Abstract excerpt

BACKGROUND: The p53 signaling pathway may be important for the pathogenesis of emphysematous changes in the lungs of smokers. Polymorphism of p53 at codon 72 is known to affect apoptotic effector proteins, and the polymorphism of mouse double minute 2 homolog (MDM2) single nucleotide polymorphism (SNP)309 is known to increase MDM2 expression. The aim of this study was to assess polymorphisms of the p53 and MDM2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28315337
DOI: 10.1016/j.chest.2017.03.012

Genes

MDM2
HLF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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