Article
Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock.
Proceedings of the National Academy of Sciences of the United States of America - 23 Jun 2009
Ferwerda Bart, Alonso Santos, Banahan Kathy, McCall Matthew B B, Giamarellos-Bourboulis Evangelos J, Ramakers Bart P, Mouktaroudi Maria, Fain Pamela R, Izagirre Neskuts, Syafruddin Din, Cristea Tudor, Mockenhaupt Frank P, Troye-Blomberg Marita, Kumpf Oliver, Maiga Boubacar, Dolo Amagana, Doumbo Ogobara, Sundaresan Santhosh, Bedu-Addo George, van Crevel Reinout, Hamann Lutz, Oh Djin-Ye, Schumann Ralf R, Joosten Leo A B, de la Rúa Concepcion, Sauerwein Robert, Drenth Joost P H, Kullberg Bart-Jan, van der Ven André J A M, Hill Adrian V, Pickkers Peter, van der Meer Jos W M, O'Neill Luke A J, Netea Mihai G
Abstract excerpt
Adequate responses by our innate immune system toward invading pathogens were of vital importance for surviving infections, especially before the antibiotic era. Recently, a polymorphism in Mal (Ser180Leu, TIRAP rs8177374), an important adaptor protein downstream of the Toll-like receptor (TLR) 2 and 4 pathways, has been described to provide protection against a broad range of infectious pathogens. We assessed...
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