A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.

doi:10.1038/ng1976

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Article

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.

Nature genetics - 1 Apr 2007

Khor Chiea C, Chapman Stephen J, Vannberg Fredrik O, Dunne Aisling, Murphy Caroline, Ling Edmund Y, Frodsham Angela J, Walley Andrew J, Kyrieleis Otto, Khan Amir, Aucan Christophe, Segal Shelley, Moore Catrin E, Knox Kyle, Campbell Sarah J, Lienhardt Christian, Scott Anthony, Aaby Peter, Sow Oumou Y, Grignani Robert T, Sillah Jackson, Sirugo Giorgio, Peshu Nobert, Williams Thomas N, Maitland Kathryn, Davies Robert J O, Kwiatkowski Dominic P, Day Nicholas P, Yala Djamel, Crook Derrick W, Marsh Kevin, Berkley James A, O'Neill Luke A J, Hill Adrian V S

Abstract excerpt

Toll-like receptors (TLRs) and members of their signaling pathway are important in the initiation of the innate immune response to a wide variety of pathogens. The adaptor protein Mal (also known as TIRAP), encoded by TIRAP (MIM 606252), mediates downstream signaling of TLR2 and TLR4 (refs. 4-6). We report a case-control study of 6,106 individuals from the UK, Vietnam and several African countries with invasive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17322885
DOI: 10.1038/ng1976
PMCID: PMC2660299

Genes

TIRAP
TLR2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.PMID 17322885Read ↗

A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling.Semantic proximity Read ↗

Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock.Semantic proximity Read ↗

Association of TLR1, TLR2, TLR4, TLR6, and TIRAP polymorphisms with disease susceptibility.Semantic proximity Read ↗

TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus.Semantic proximity Read ↗

MyD88 adaptor-like D96N is a naturally occurring loss-of-function variant of TIRAP.Semantic proximity Read ↗

Mal, more than a bridge to MyD88Semantic proximity Read ↗

Genetic variation in Toll-like receptor signalling and the risk of inflammatory and immune diseases.Semantic proximity Read ↗

Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy.Semantic proximity Read ↗

A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.Semantic proximity Read ↗

Association of Mal/TIRAP S180L variant polymorphism with decreased infection risk in patients with advanced HIV-1 infection.Semantic proximity Read ↗

Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious diseases.Semantic proximity Read ↗

Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populationsSemantic proximity Read ↗

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