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Article

A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.

The Journal of biological chemistry - 18 Sept 2009

Nagpal Kamalpreet, Plantinga Theo S, Wong Joyce, Monks Brian G, Gay Nicholas J, Netea Mihai G, Fitzgerald Katherine A, Golenbock Douglas T

Abstract excerpt

The adapter protein MyD88 adapter-like (Mal), encoded by TIR-domain containing adapter protein (Tirap) (MIM 606252), is the most polymorphic of the five adapter proteins involved in Toll-like receptor signaling, harboring eight non-synonymous single nucleotide polymorphisms in its coding region. We screened reported mutations of Mal for activity in reporter assays to test the hypothesis that variants of Mal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19509286
DOI: 10.1074/jbc.M109.014886
PMCID: PMC2757976

Genes

TIRAP
TLR2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.PMID 19509286Read ↗

MyD88 adaptor-like D96N is a naturally occurring loss-of-function variant of TIRAP.Semantic proximity Read ↗

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