Article
Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy.
BMC medical genetics - 14 Jul 2009
Hamann Lutz, Kumpf Oliver, Schuring Ron P, Alpsoy Erkan, Bedu-Addo George, Bienzle Ulrich, Oskam Linda, Mockenhaupt Frank P, Schumann Ralf R
Abstract excerpt
BACKGROUND: The Toll-like receptors (TLRs) mediate innate immunity to various pathogens. A mutation (S180L) in the TLR downstream signal transducer TIRAP has recently been reported to be common in Europeans and Africans and to roughly half the risks of heterogeneous infectious diseases including malaria, tuberculosis, bacteremia, and invasive pneumococal disease in heterozygous mutation carriers. METHODS: We...
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