Article
TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans.
Proceedings of the National Academy of Sciences of the United States of America - 16 Oct 2007
Ferwerda Bart, McCall Matthew B B, Alonso Santos, Giamarellos-Bourboulis Evangelos J, Mouktaroudi Maria, Izagirre Neskuts, Syafruddin Din, Kibiki Gibson, Cristea Tudor, Hijmans Anneke, Hamann Lutz, Israel Shoshana, ElGhazali Gehad, Troye-Blomberg Marita, Kumpf Oliver, Maiga Boubacar, Dolo Amagana, Doumbo Ogobara, Hermsen Cornelus C, Stalenhoef Anton F H, van Crevel Reinout, Brunner Han G, Oh Djin-Ye, Schumann Ralf R, de la Rúa Concepcion, Sauerwein Robert, Kullberg Bart-Jan, van der Ven André J A M, van der Meer Jos W M, Netea Mihai G
Abstract excerpt
Infectious diseases exert a constant evolutionary pressure on the genetic makeup of our innate immune system. Polymorphisms in Toll-like receptor 4 (TLR4) have been related to susceptibility to Gram-negative infections and septic shock. Here we show that two polymorphisms of TLR4, Asp299Gly and Thr399Ile, have unique distributions in populations from Africa, Asia, and Europe. Genetic and functional studies are...
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