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Article

Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts.

Critical care (London, England) - 1 Jan 2010

Kumpf Oliver, Giamarellos-Bourboulis Evangelos J, Koch Alexander, Hamann Lutz, Mouktaroudi Maria, Oh Djin-Ye, Latz Eicke, Lorenz Eva, Schwartz David A, Ferwerda Bart, Routsi Christina, Skalioti Chryssanthi, Kullberg Bart-Jan, van der Meer Jos W M, Schlag Peter M, Netea Mihai G, Zacharowski Kai, Schumann Ralf R

Abstract excerpt

INTRODUCTION: It has been proposed that individual genetic variation contributes to the course of severe infections and sepsis. Recent studies of single nucleotide polymorphisms (SNPs) within the endotoxin receptor and its signaling system showed an association with the risk of disease developmen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20525286
DOI: 10.1186/cc9047
PMCID: PMC2911747

Genes

TIRAP
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20525286-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts.PMID 20525286Read ↗

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