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Article

A common human TLR1 polymorphism regulates the innate immune response to lipopeptides.

European journal of immunology - 1 Aug 2007

Hawn Thomas R, Misch E Ann, Dunstan Sarah J, Thwaites Guy E, Lan Nguyen T N, Quy Hoang T, Chau Tran T H, Rodrigues Stephanie, Nachman Alex, Janer Marta, Hien Tran T, Farrar Jeremy J, Aderem Alan

Abstract excerpt

Toll-like receptors (TLR) are critical mediators of the immune response to pathogens and human polymorphisms in this gene family regulate inflammatory pathways and are associated with susceptibility to infection. Lipopeptides are present in a wide variety of microbes and stimulate immune responses through TLR1/2 or TLR2/6 heterodimers. It is not currently known whether polymorphisms in TLR1 regulate the innate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17595679
DOI: 10.1002/eji.200737034

Genes

TLR1
TLR2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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