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Article

Association of Mal/TIRAP S180L variant polymorphism with decreased infection risk in patients with advanced HIV-1 infection.

Cytokine - 1 Oct 2012

Papadopoulos Antonios I, Ferwerda Bart, Antoniadou Anastasia, Sakka Vissaria, Galani Lambrini, Kavatha Dimitra, Panagopoulos Periklis, Poulakou Garyphalia, Protopapas Konstantinos, van der Meer Jos W M, Netea Mihai G, Giamarellos-Bourboulis Evangelos J

Abstract excerpt

OBJECTIVES: MyD88 adaptor-like (Mal/TIRAP) is an adaptor protein bridging activation of Toll-like receptors 2 and 4 after stimulation by exogenous and endogenous ligands. We investigated the association between the presence of the S180L SNP of Mal and the risk of severe infection in individuals with human immunodeficiency virus (HIV)-1 infection. METHODS: The SNP S180L was determined in a cohort of 179 HIV-1...

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Source

Identifiers

PMID: 22683004
DOI: 10.1016/j.cyto.2012.05.008

Genes

TIRAP

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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