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Article

Heterozygous mutants of TIRAP (S180L) polymorphism protect adult patients with Plasmodium falciparum infection against severe disease and mortality.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Sept 2016

Panda Aditya K, Das Bidyut K, Panda Abhinash, Tripathy Rina, Pattnaik Sarit S, Mahto Harishankar, Pied Sylviane, Pathak Sulabha, Sharma Shobhona, Ravindran Balachandran

Abstract excerpt

Toll-interleukin-1 receptor domain containing adapter protein (TIRAP) plays a crucial role in TLR2 and TLR4 signaling pathways. Glycosylphospatidylinositol (GPI), considered a toxin molecule of Plasmodium falciparum, interacts with TLR2 and 4 to induce an immune inflammatory response. A single nucleotide polymorphism at coding region of TIRAP (S180L) has been reported to influence TLRs signaling. In the present...

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Source

Identifiers

PMID: 27166096
DOI: 10.1016/j.meegid.2016.04.035

Genes

TIRAP
TLR2
TNF
GPI
TLR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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