A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling.

doi:10.1016/j.immuni.2016.01.019

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Article

A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling.

Immunity - 16 Feb 2016

Ní Cheallaigh Clíona, Sheedy Frederick J, Harris James, Muñoz-Wolf Natalia, Lee Jinhee, West Kim, McDermott Eva Palsson, Smyth Alicia, Gleeson Laura E, Coleman Michelle, Martinez Nuria, Hearnden Claire H A, Tynan Graham A, Carroll Elizabeth C, Jones Sarah A, Corr Sinéad C, Bernard Nicholas J, Hughes Mark M, Corcoran Sarah E, O'Sullivan Mary, Fallon Ciara M, Kornfeld Hardy, Golenbock Douglas, Gordon Stephen V, O'Neill Luke A J, Lavelle Ed C, Keane Joseph

Abstract excerpt

Humans that are heterozygous for the common S180L polymorphism in the Toll-like receptor (TLR) adaptor Mal (encoded by TIRAP) are protected from a number of infectious diseases, including tuberculosis (TB), whereas those homozygous for the allele are at increased risk. The reason for this difference in susceptibility is not clear. We report that Mal has a TLR-independent role in interferon-gamma (IFN-γ) receptor...

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Identifiers

PMID: 26885859
DOI: 10.1016/j.immuni.2016.01.019
PMCID: PMC4760121

Genes

TIRAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling.PMID 26885859Read ↗

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