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Article

Genetic variants in the TIRAP gene are associated with increased risk of sepsis-associated acute lung injury.

BMC medical genetics - 30 Nov 2010

Song Zhenju, Tong Chaoyang, Sun Zhan, Shen Yao, Yao Chenling, Jiang Jinjun, Yin Jun, Gao Lei, Song Yuanlin, Bai Chunxue

Abstract excerpt

BACKGROUND: Toll like receptors (TLRs) signaling pathways, including the adaptor protein Mal encoded by the TIRAP gene, play a central role in the development of acute lung injury (ALI). Recently, the TIRAP variants have been described association with susceptibility to inflammatory diseases. The aim of this study was to investigate whether genetic variants in TIRAP are associated with the development of ALI....

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Source

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Identifiers

PMID: 21118491
DOI: 10.1186/1471-2350-11-168
PMCID: PMC3001691

Genes

TIRAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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