Article
A random shRNA-encoding library for phenotypic selection and hit-optimization.
PloS one - 9 Sept 2008
Wang Yongping, Wang Yun E, Cotticelli M Grazia, Wilson Robert B
Abstract excerpt
RNA interference (RNAi) is a mechanism for inhibiting gene expression through the action of small, non-coding RNAs. Most existing RNAi libraries target single genes through canonical pathways. Endogenous microRNAs (miRNAs), however, often target multiple genes and can act through non-canonical pathways, including pathways that activate gene expression. To interrogate all possible functions, we designed,...
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