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Article

shRNAs Targeting Hepatitis C: Effects of Sequence and Structural Features, and Comparision with siRNA

1 Jun 2007

Abstract excerpt

Hepatitis C virus (HCV) is a leading cause of liver cirrhosis and hepatocellular carcinoma worldwide. Currently available treatment options are of limited efficacy, and there is an urgent need for development of alternative therapies. RNA interference (RNAi) is a natural mechanism by which small interfering RNA (siRNA) or short hairpin RNA (shRNA) can mediate degradation of a target RNA molecule in a...

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Identifiers

PMID: 17638526
DOI: 10.1089/oli.2006.0069

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