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Article

Inhibition of HIV-1 replication by siRNA targeting conserved regions of gag/pol.

RNA biology - 1 Jan 2005

Morris Kevin V, Chung Chris H, Witke Werner, Looney David J

Abstract excerpt

Short interfering RNAs (siRNAs) targeting HIV-1gag, vif, tat, rev and host CD4 and CCR5 have been reported to inhibit HIV replication. However, the sequence divergence of HIV and the concentration dependence of siRNA activity represent significant challenges to RNAi mediated inhibition. To determine the parameters of RNAi in suppression of HIV-1 we screened seven siRNA candidates targeting highly conserved...

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Share to Conserved Sequence
Share to Genes, gag
Share to Genes, pol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to RNA Interference

Share to RNA, Small Interfering

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Source

Identifiers

PMID: 17132935
DOI: 10.4161/rna.2.1.1198

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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