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Article

Sequence homology required by human immunodeficiency virus type 1 to escape from short interfering RNAs.

Journal of virology - 1 Jan 2006

Sabariegos Rosario, Giménez-Barcons Mireia, Tàpia Natalia, Clotet Bonaventura, Martínez Miguel Angel

Abstract excerpt

Short interfering RNAs (siRNAs) targeting viral or cellular genes can efficiently inhibit human immunodeficiency virus type 1 (HIV-1) replication. Nevertheless, the emergence of mutations in the gene being targeted could lead to the rapid escape from the siRNA. Here, we simulate viral escape by systematically introducing single-nucleotide substitutions in all 19 HIV-1 residues targeted by an effective siRNA. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16378959
DOI: 10.1128/JVI.80.2.571-577.2006
PMCID: PMC1346856

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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